Trends in the diagnosis of variant bladder cancer: a national retrospective cohort analysis - Takeaways - MDSpire

Trends in the diagnosis of variant bladder cancer: a national retrospective cohort analysis

  • By

  • Syed N. Rahman

  • Kandala Keervani

  • Xiwen Zhao

  • Curtis J. Perry

  • Ping Mu

  • Darryl Martin

  • Wei Shen Tan

  • David G. Hesse

  • Daniel P. Petrylak

  • Joshua Warrick

  • Deepika Kumar

  • Peter A. Humphrey

  • Fady Ghali

  • May 11, 2026

  • 0 min

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  • 1

    The diagnosis of variant bladder cancer (VBC) increased from 3.5% to 4.3% of bladder cancer cases between 2004 and 2021.

  • 2

    The rise in VBC diagnosis was particularly noted in micropapillary, sarcomatoid, and neuroendocrine subtypes.

  • 3

    VBC diagnosis trends were consistent across various facility types, including community and academic cancer programs.

  • 4

    Multivariable regression indicated significant associations between VBC diagnosis and factors like race, clinical stage, and facility type.

  • 5

    The findings highlight the growing need for centralized review due to the increasing recognition of VBC in clinical practice.

Original Source(s)

Trends in the diagnosis of variant bladder cancer: a national retrospective cohort analysis

  • by Syed N. Rahman, Kandala Keervani, Xiwen Zhao, Curtis J. Perry, Ping Mu, Darryl Martin, Wei Shen Tan, David G. Hesse, Daniel P. Petrylak, Joshua Warrick, Deepika Kumar, Peter A. Humphrey, Fady Ghali

  • May 11, 2026

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