VANGL1 links angiogenesis–stemness programs and tumor microenvironment remodeling: a pan-cancer, multi-omics study with translational validation

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VANGL1 is significantly upregulated in solid tumors and correlates with poor prognosis across 33 tumor types.
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Single-cell analysis shows VANGL1+ malignant cells enhance communication with fibroblasts, endothelial, and immune cells.
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VANGL1 integrates Wnt/Notch/mTOR signaling with cancer stemness and angiogenesis, influencing tumor microenvironment.
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Knock-down of VANGL1 suppresses cancer cell proliferation, migration, invasion, and reduces tumor growth in vivo.
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The study identifies VANGL1 as a master regulator of tumor microenvironment alterations, suggesting therapeutic targeting.

Frontiers In Oncology

by Wei Zhou, Lizhen Wang, Mengxing Li, Xuan Liu, Qing Fang, Yang Yu, Songjie Zhang, Jing Guo, Rui Chang, Cheng Zhang, Tongliang Zhou, Yang Liu, Xiaoxia Ren, Honglin Liu, Lihong Liu
May 29, 2026

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