Association of peripheral blood LUBAC and OTULIN expression with severity and outcome in acute ischemic stroke: a prospective cohort study - Takeaways - MDSpire

Association of peripheral blood LUBAC and OTULIN expression with severity and outcome in acute ischemic stroke: a prospective cohort study

  • By

  • Wei Chen

  • Zewen Chen

  • Hongqun Chen

  • Jun Li

  • Jiayan Xie

  • Xinyao Chen

  • Hongbei Xu

  • May 20, 2026

  • 0 min

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  • 1

    The study assessed the association of LUBAC and OTULIN levels in peripheral blood with stroke severity and functional outcomes in acute ischemic stroke patients.

  • 2

    Peripheral blood levels of HOIP and OTULIN were significantly higher in acute ischemic stroke patients compared to healthy controls.

  • 3

    HOIP was positively associated with stroke severity and poor functional outcomes, while OTULIN was negatively associated with stroke severity.

  • 4

    A significant interaction between HOIP and OTULIN was observed, indicating their combined effect on stroke severity.

  • 5

    HOIP demonstrated good discriminative ability for poor outcomes, suggesting its potential as a biomarker for assessing stroke prognosis.

Original Source(s)

Association of peripheral blood LUBAC and OTULIN expression with severity and outcome in acute ischemic stroke: a prospective cohort study

  • by Wei Chen, Zewen Chen, Hongqun Chen, Jun Li, Jiayan Xie, Xinyao Chen, Hongbei Xu

  • May 20, 2026

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