Researchers identified Asian longhorned tick nairovirus (ALTNV), a previously unknown orthonairovirus, in patients with fever and tick exposure in China.
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Among 3,163 patients with fever and recent tick exposure, 10.4% had ALTNV RNA or immunoglobulin M antibodies; 15.1% of those testing negative for Dabie bandavirus had evidence of ALTNV infection.
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Among 56 patients infected only with ALTNV, fatigue occurred in 84%, gastrointestinal symptoms in 80%, thrombocytopenia in 38%, and elevated aminotransferase levels in 36%; all recovered without repor
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Among 38 patients coinfected with ALTNV and Dabie bandavirus, respiratory symptoms and kidney impairment were more frequent than in patients with Dabie bandavirus alone, and 7 coinfected patients died
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ALTNV RNA was detected in 1.29% of 47,428 ticks, and laboratory experiments showed that Haemaphysalis longicornis could transmit the virus to mice.
