Exploratory characterization of IgG1/IgG4 glycosylation and monocyte-derived dendritic cell responses in esophageal squamous cell carcinoma

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IgG4 levels and CD11c+ cell densities are significantly higher in esophageal squamous cell carcinoma tissues compared to adjacent normal tissues.
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IgG4 exhibits distinct glycosylation profiles, primarily high-mannose glycosylation, differentiating it from IgG1 and commercial myeloma-derived IgG4.
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Monocyte-derived dendritic cells show strong binding affinity for IgG1 but weak affinity for IgG4, affecting their functional responses.
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In vitro co-culture studies indicate that IgG4 enhances the migration and phagocytic capacity of monocyte-derived dendritic cells compared to IgG1.
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The study suggests that IgG4's glycosylation may influence monocyte-derived dendritic cell activity, warranting further investigation in larger cohorts.

Frontiers In Immunology

by Hui Wang, Jun Li, Yinghai Wang, Yuebin Shi, Peiren Tang, Ying Li, Jiang Gu, Li Wang
June 18, 2026

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