Head and neck squamous cell carcinoma with femoral metastasis: a case report and systematic review of current literature - Takeaways - MDSpire

Head and neck squamous cell carcinoma with femoral metastasis: a case report and systematic review of current literature

  • By

  • Hannah Chahal

  • Joseph Latham

  • Finlay Ajayi

  • Sasan Dehbozorgi

  • Andrew Miller

  • Gordon Gillespie

  • July 6, 2026

  • 0 min

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  • 1

    Femoral metastasis from head and neck squamous cell carcinoma (HNSCC) is exceptionally rare, with most cases involving the tongue as the primary site.

  • 2

    A systematic review identified six cases of femoral metastasis from HNSCC, with a mean patient age of 57 years and a male predominance of 66.7%.

  • 3

    Time to femoral metastasis varied from six months to 19 years, often associated with advanced disease and early recurrence.

  • 4

    Management of femoral metastasis was primarily palliative, including radiotherapy and orthopaedic interventions for fractures.

  • 5

    Overall prognosis for patients with femoral metastasis from HNSCC is poor, reflecting aggressive tumor biology and limited treatment options.

Original Source(s)

Head and neck squamous cell carcinoma with femoral metastasis: a case report and systematic review of current literature

  • by Hannah Chahal, Joseph Latham, Finlay Ajayi, Sasan Dehbozorgi, Andrew Miller, Gordon Gillespie

  • July 6, 2026

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