Femoral Metastasis in Head and Neck Squamous Cell Carcinoma: A Case Study and Comprehensive Literature Review

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Femoral metastasis from head and neck squamous cell carcinoma (HNSCC) is exceptionally rare, with most cases involving the tongue as the primary site.
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A systematic review identified six cases of femoral metastasis from HNSCC, with a mean patient age of 57 years and a male predominance of 66.7%.
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Time to femoral metastasis varied from six months to 19 years, often associated with advanced disease and early recurrence.
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Management of femoral metastasis was primarily palliative, including radiotherapy and orthopaedic interventions for fractures.
5

Overall prognosis for patients with femoral metastasis from HNSCC is poor, reflecting aggressive tumor biology and limited treatment options.

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