Case Report: Beyond two years: a neurosurgical review of prolonged survival and late recurrence in IDH-wildtype GBM - Takeaways - MDSpire

Case Report: Beyond two years: a neurosurgical review of prolonged survival and late recurrence in IDH-wildtype GBM

  • By

  • Hasan Ali Aydın

  • Emrah Keskin

  • Murat Kalaycı

  • May 11, 2026

  • 0 min

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  • 1

    IDH-wildtype glioblastoma multiforme (GBM) has a median survival of 12–15 months despite aggressive treatment.

  • 2

    A rare subset of patients, 1% to 5%, survives beyond two years, often linked to gross total resection and favorable molecular profiles.

  • 3

    Neurosurgery plays a critical role in improving outcomes for GBM, with gross total resection extending survival significantly.

  • 4

    Late recurrence of GBM is uncommon and poses unique diagnostic challenges, including the risk of pseudoprogression.

  • 5

    Advanced imaging techniques and refined surgical approaches are essential for managing IDH-wildtype GBM effectively.

Original Source(s)

Case Report: Beyond two years: a neurosurgical review of prolonged survival and late recurrence in IDH-wildtype GBM

  • by Hasan Ali Aydın, Emrah Keskin, Murat Kalaycı

  • May 11, 2026

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