Maternal high-fat diet exposure is associated with altered hypothalamic microglial development and reduced early postnatal TGFβ1 signaling in male offspring - Takeaways - MDSpire

Maternal high-fat diet exposure is associated with altered hypothalamic microglial development and reduced early postnatal TGFβ1 signaling in male offspring

  • By

  • Nan Chen

  • Huabin Ye

  • Yi Ren

  • June 22, 2026

  • 0 min

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  • 1

    Maternal high-fat diet exposure disrupts hypothalamic microglial development in male offspring, affecting energy homeostasis.

  • 2

    Microglia in male offspring progressively acquire homeostatic features during early postnatal development, influenced by TGFβ1 signaling.

  • 3

    Maternal high-fat diet leads to reduced TMEM119+ microglia and altered microglial morphology in the mediobasal hypothalamus.

  • 4

    Neonatal supplementation with TGFβ1 enhances microglial features, increasing pSMAD3 immunoreactivity and TMEM119-positive cell abundance.

  • 5

    These findings indicate a link between maternal high-fat diet, impaired TGFβ1 signaling, and altered microglial development in male offspring.

Original Source(s)

Maternal high-fat diet exposure is associated with altered hypothalamic microglial development and reduced early postnatal TGFβ1 signaling in male offspring

  • by Nan Chen, Huabin Ye, Yi Ren

  • June 22, 2026

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