Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and - Takeaways - MDSpire

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and

  • By

  • Nazmul Islam

  • Alexandro W. L. Chu

  • Falana Sheriff

  • Farid Foroutan

  • Gordon H. Guyatt

  • Romina Brignardello-Petersen

  • Paul Oykhman

  • Alfonso Iorio

  • Ariel Izcovich

  • Katherine M. Morrison

  • Yetiani Roldan Benitez

  • Rachel J. Couban

  • Dorota Borovsky

  • Yiming Zhang

  • Leonardo Ologundudu

  • Keerthana Pasumarthi

  • Syed Fahad Farooq

  • Kyle Tong

  • Wang-Choi Tang

  • Haseeb Faisal

  • Muhammad Faran Khalid

  • Mohammad Saad Asif

  • Shannon French

  • Susan Waserman

  • R. Sharon Chinthrajah

  • Hugh A. Sampson

  • S. Shahzad Mustafa

  • Jay A. Lieberman

  • Kirsi M. Järvinen

  • Sally Bailey

  • Philippe Bégin

  • Scott H. Sicherer

  • Jennifer Gerdts

  • Melanie Carver

  • Lynda Mitchell

  • Kelly Cleary

  • Matthew J. Greenhawt

  • Julie Wang

  • Aikaterini Anagnostou

  • Marcus S. Shaker

  • Anita Chandra-Puri

  • Patricia C. Fulkerson

  • Robert A. Wood

  • Derek K. Chu

  • May 1, 2026

  • 0 min

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  • 1

    Food allergy affects over 33 million people in the US and is primarily IgE-mediated, often developing early in life and causing severe reactions.

  • 2

    There is no consensus on at-risk populations for food allergy, complicating prevention strategies and leaving stakeholders without clear guidance.

  • 3

    The systematic review followed established guidelines and included studies that confirmed food allergy through food challenges.

  • 4

    Risk factors for food allergy were assessed using multivariable-adjusted analyses, with a focus on children aged 6 years or younger.

  • 5

    The study employed rigorous methods to evaluate the quality of evidence for risk factors, using the GRADE approach to rate certainty.

Original Source(s)

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and

  • by Nazmul Islam, Alexandro W. L. Chu, Falana Sheriff, Farid Foroutan, Gordon H. Guyatt, Romina Brignardello-Petersen, Paul Oykhman, Alfonso Iorio, Ariel Izcovich, Katherine M. Morrison, Yetiani Roldan Benitez, Rachel J. Couban, Dorota Borovsky, Yiming Zhang, Leonardo Ologundudu, Keerthana Pasumarthi, Syed Fahad Farooq, Kyle Tong, Wang-Choi Tang, Haseeb Faisal, Muhammad Faran Khalid, Mohammad Saad Asif, Shannon French, Susan Waserman, R. Sharon Chinthrajah, Hugh A. Sampson, S. Shahzad Mustafa, Jay A. Lieberman, Kirsi M. Järvinen, Sally Bailey, Philippe Bégin, Scott H. Sicherer, Jennifer Gerdts, Melanie Carver, Lynda Mitchell, Kelly Cleary, Matthew J. Greenhawt, Julie Wang, Aikaterini Anagnostou, Marcus S. Shaker, Anita Chandra-Puri, Patricia C. Fulkerson, Robert A. Wood, Derek K. Chu

  • May 1, 2026

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