Roxadustat Treatment After PCI Among Patients With ST-Segment Elevation Myocardial Infarction: A Randomized - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Randomized Evaluation of Roxadustat Therapy Following PCI in Patients With ST-Segment Elevation Myocardial Infarction

  • By

  • Weiwei Quan

  • Yueying Wang

  • Min Zhang

  • Tianqi Zhu

  • Jinzhou Zhu

  • Xiaoqun Wang

  • Zhengbin Zhu

  • Run Du

  • Fenghua Ding

  • Jingwei Ni

  • Shuo Feng

  • Hongyang Xie

  • Lili Liu

  • Yuehua Fang

  • Xuezheng Qu

  • Ruiyan Zhang

  • Xiaoxiang Yan

  • October 9, 2026

Share

  • 1

    The ROXAMI trial tested whether roxadustat started after primary PCI could reduce infarct size and improve functional outcomes in patients with STEMI.

  • 2

    This prospective, open-label, randomized trial enrolled adults with STEMI who presented within 12 hours of symptom onset and underwent primary PCI.

  • 3

    Participants were randomized 1:1 to standard care with or without roxadustat, initiated within 2 hours after PCI at 100 mg 3 times weekly for 2 weeks.

  • 4

    The prespecified primary end point was infarct size as a percentage of left ventricular volume, assessed by PET and MRI at a mean of 30 days after presentation.

  • 5

    Prespecified secondary end points included major adverse cardiovascular events, myocardial injury markers, echocardiographic measures, and myocardial fibroblast activation parameters.

Original Source(s)

Roxadustat Treatment After PCI Among Patients With ST-Segment Elevation Myocardial Infarction: A Randomized

  • by Weiwei Quan, Yueying Wang, Min Zhang, Tianqi Zhu, Jinzhou Zhu, Xiaoqun Wang, Zhengbin Zhu, Run Du, Fenghua Ding, Jingwei Ni, Shuo Feng, Hongyang Xie, Lili Liu, Yuehua Fang, Xuezheng Qu, Ruiyan Zhang, Xiaoxiang Yan

  • October 9, 2026

Related Content

Female patients less likely to receive invasive care

Review identifies recurring sex-based differences across specialties, including lower use of intensive and guideline-compliant treatment among female patients.

Simplified radial artery haemostasis: using non-compressive dressings—the Radial Artery Puncture Haemostasis Evaluation trial: results of the RAPHE trial

Acute inferior STEMI in a unique setting: case report on anomalous circumflex and multivessel coronary artery disease