Inflammatory-metabolic alterations in asthma-COPD overlap compared with COPD: evidence from NHANES and a hospital-based cohort - Takeaways - MDSpire

Inflammatory-metabolic alterations in asthma-COPD overlap compared with COPD: evidence from NHANES and a hospital-based cohort

  • By

  • Xiaofei Yi

  • Yufen Fu

  • Yuxin Wang

  • Shiyue Li

  • Guoping Li

  • June 26, 2026

  • 0 min

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  • 1

    Asthma-chronic obstructive pulmonary disease overlap (ACO) exhibits a distinct inflammatory-metabolic profile compared to COPD.

  • 2

    Participants with ACO showed a greater inflammatory-metabolic burden than those with asthma alone, COPD alone, or neither condition.

  • 3

    Multinomial logistic regression identified several inflammatory and metabolic biomarkers significantly associated with ACO.

  • 4

    LASSO regression identified specific candidate biomarkers for distinguishing ACO from COPD in both NHANES and hospital cohorts.

  • 5

    The study highlights the need for integrative inflammatory-metabolic indices to better characterize ACO and differentiate it from COPD.

Original Source(s)

Inflammatory-metabolic alterations in asthma-COPD overlap compared with COPD: evidence from NHANES and a hospital-based cohort

  • by Xiaofei Yi, Yufen Fu, Yuxin Wang, Shiyue Li, Guoping Li

  • June 26, 2026

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