Evaluation of a 47Sc-labeled PDGFRβ-targeting affibody for SPECT imaging and radiotherapy applications in pancreatic cancer - Takeaways - MDSpire

Evaluation of a 47Sc-labeled PDGFRβ-targeting affibody for SPECT imaging and radiotherapy applications in pancreatic cancer

  • By

  • Ruomeng Liu

  • Dongping Su

  • Yuhao Liao

  • Zhao Li

  • Bo Li

  • Yunming Chen

  • Qi Cao

  • Jinsong Zhang

  • Huawei Cai

  • January 5, 2026

  • 0 min

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  • 1

    Pancreatic cancer has a poor prognosis, characterized by high invasiveness, recurrence, and treatment resistance.

  • 2

    CAFs play a significant role in pancreatic cancer progression by modifying the tumor microenvironment and promoting fibrosis.

  • 3

    PDGFRβ is highly expressed in CAFs and serves as a promising target for molecular imaging and therapy in pancreatic cancer.

  • 4

    47Sc is a promising radionuclide for SPECT imaging and radiotherapy due to its suitable half-life and favorable emission properties.

  • 5

    The study aims to label an affibody with 47Sc to enhance the diagnosis and treatment of pancreatic cancer.

Original Source(s)

Evaluation of a 47Sc-labeled PDGFRβ-targeting affibody for SPECT imaging and radiotherapy applications in pancreatic cancer

  • by Ruomeng Liu, Dongping Su, Yuhao Liao, Zhao Li, Bo Li, Yunming Chen, Qi Cao, Jinsong Zhang, Huawei Cai

  • January 5, 2026

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