Prospective phase II study of frontline Helicobacter pylori eradication therapy for early-stage extragastric mucosa-associated lymphoid tissue lymphoma

1

The study enrolled 26 patients with localized extragastric MALT lymphoma to evaluate frontline Helicobacter pylori eradication treatment.
2

The overall response rate to frontline HPE was 65.4%, with 38.5% achieving complete remission and 26.9% achieving partial remission.
3

Patients achieving complete remission had a median duration of lymphoma-free survival of 78.8 months after treatment.
4

The 7-year event-free survival rate for all patients was 76.5%, while the overall survival rate was 95.8%.
5

The presence of Helicobacter pylori infection showed a trend toward better response to antibiotic treatment in patients.

Blood Cancer Journal

by Ming Yao, Xavier Cheng-Hong Tsai, Chung-Wu Lin, Shu-Lang Liao, Cheng-Ping Wang, Wei-Li Ma, Yi-Hsuan Wei, Hsiao-Wei Lee, Jyh-Ming Liou, Wei-Li Chen, I-Jong Wang, Ann-Lii Cheng, Sung-Hsin Kuo
May 29, 2026

1