Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic - Takeaways - MDSpire

Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic

  • By

  • Huiying Liu

  • Xunjun Li

  • Jiang Yu

  • Tao Chen

  • May 13, 2026

  • 0 min

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  • 1

    The nervous system significantly influences tumor initiation, progression, and metastasis within the tumor microenvironment.

  • 2

    Tumors can remodel peripheral nerves, enhancing their own growth and survival through neuro-immune interactions.

  • 3

    Neurotrophins like NGF and BDNF play critical roles in axonogenesis and peripheral nerve remodeling in the tumor microenvironment.

  • 4

    The review highlights integrated therapeutic strategies targeting neuro-immune crosstalk to improve cancer treatment outcomes.

  • 5

    Understanding the mechanisms of neuro-immune interactions is essential for developing precision therapies against cancer.

Original Source(s)

Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic

  • by Huiying Liu, Xunjun Li, Jiang Yu, Tao Chen

  • May 13, 2026

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