Risk-adapted trajectory selection for ultrasound-guided thyroid fine-needle aspiration biopsy: a multicenter study of in-plane and out-of-plane approaches - Takeaways - MDSpire

Risk-adapted trajectory selection for ultrasound-guided thyroid fine-needle aspiration biopsy: a multicenter study of in-plane and out-of-plane approaches

  • By

  • Xiubin Tang

  • Wenjin Lin

  • Youhai Wu

  • Ming Chen

  • Xiao Yang

  • July 17, 2026

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  • 1

    This study evaluated needle approach strategies in ultrasound-guided fine-needle aspiration biopsy (FNAB) for thyroid nodules.

  • 2

    The study included 506 thyroid nodules from three tertiary hospitals, comparing in-plane and out-of-plane needle approaches.

  • 3

    Diagnostic adequacy was significantly higher with the in-plane approach (98.3%) compared to the out-of-plane approach (85.7%).

  • 4

    Satisfactory needle-tip visualization occurred more frequently with the in-plane approach (97.2%) than with the out-of-plane approach (63.6%).

  • 5

    Immediate hematoma rates were similar between both approaches, indicating no significant safety difference in this study.

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