Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p - Takeaways - MDSpire

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p

  • By

  • Jian Xiong

  • Ying Wei

  • Yunnan Liu

  • Fayang Ling

  • Yi Zhao

  • Yu Liu

  • Yuxin Sun

  • Dehua Li

  • Mingsheng Sun

  • Dingjun Cai

  • Wenchuan Qi

  • Qianhua Zheng

  • Fanrong Liang

  • June 1, 2026

  • 0 min

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  • 1

    Electroacupuncture (EA) reduces myocardial ischemia-reperfusion injury (MIRI) by inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis.

  • 2

    The study established an animal model of MIRI and applied EA at the Neiguan (PC6) acupoint to assess its therapeutic effects.

  • 3

    EA was shown to alleviate MIRI by targeting NLRP3-mediated myocardial apoptosis, confirmed through various assessment methods.

  • 4

    Serum exosomes from patients and MIRI model rats revealed that miR-22-3p was significantly upregulated following EA treatment.

  • 5

    miR-22-3p mitigates MIRI by targeting NLRP3 to inhibit cardiomyocyte pyroptosis, as validated through in vitro and in vivo studies.

Original Source(s)

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p

  • by Jian Xiong, Ying Wei, Yunnan Liu, Fayang Ling, Yi Zhao, Yu Liu, Yuxin Sun, Dehua Li, Mingsheng Sun, Dingjun Cai, Wenchuan Qi, Qianhua Zheng, Fanrong Liang

  • June 1, 2026

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