Reduced plasma levels of Copine 5 correlate with sepsis-induced vascular leakage and mortality in human patients and a murine sepsis model - Takeaways - MDSpire

Reduced plasma levels of Copine 5 correlate with sepsis-induced vascular leakage and mortality in human patients and a murine sepsis model

  • By

  • Mingliang Pan

  • Zhixin Li

  • Xiaohong Wang

  • Tianyuan Yang

  • Jingqi Li

  • Wei Huang

  • Hongkuan Fan

  • Nebahat Ece Kesten

  • Tianqing Peng

  • Liying Zhan

  • Guo-Chang Fan

  • November 19, 2025

  • 0 min

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  • 1

    Lowered plasma concentrations of Copine 5 are linked to increased vascular leakage in sepsis patients.

  • 2

    Sepsis has a high mortality rate of 30-50%, necessitating better understanding of its molecular mechanisms.

  • 3

    Current biomarkers for sepsis prognosis, like Ang-II and sICAM-1, lack sufficient predictive accuracy.

  • 4

    CPNE5 is predominantly expressed in aortic endothelial cells and may serve as a prognostic indicator in sepsis.

  • 5

    The study utilized both human plasma samples and murine models to validate the role of CPNE5 in sepsis.

Original Source(s)

Reduced plasma levels of Copine 5 correlate with sepsis-induced vascular leakage and mortality in human patients and a murine sepsis model

  • by Mingliang Pan, Zhixin Li, Xiaohong Wang, Tianyuan Yang, Jingqi Li, Wei Huang, Hongkuan Fan, Nebahat Ece Kesten, Tianqing Peng, Liying Zhan, Guo-Chang Fan

  • November 19, 2025

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