Positive Urine Cytology Reveals Melanoma - Takeaways - MDSpire

Positive Urine Cytology Reveals Melanoma

Rare case links prior melanoma in situ to ureter and porta hepatis metastases

  • By

  • Jess Allerton

  • February 16, 2026

  • 3 min

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  • 1

    A 77-year-old woman developed metastatic melanoma four years after excision of a melanoma in situ lesion.

  • 2

    Metastases were confirmed through histopathology, immunohistochemistry, and urine cytology, involving the ureter and porta hepatis.

  • 3

    Urine cytology revealed atypical cells similar to those found in the ureteric biopsy, indicating metastatic melanoma.

  • 4

    Metastasis to the genitourinary tract is rare, occurring in 0.2% to 1% of melanoma cases, complicating diagnosis.

  • 5

    The case highlights the importance of considering metastatic melanoma in atypical ureteral tumors, requiring thorough diagnostic evaluation.

Original Source(s)

Positive Urine Cytology Reveals Melanoma

  • by Jess Allerton

  • February 16, 2026

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