State-dependent facial pulsation asymmetry and phase asynchrony measured by imaging photoplethysmography and their coupling with contingent negative variation in migraine

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The study enrolled 78 migraine patients and 72 healthy controls to evaluate facial hemodynamic alterations using imaging photoplethysmography.
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Bilateral pulsation amplitude asymmetry and phase difference were significantly higher in migraine patients compared to healthy controls.
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Contingent negative variation metrics showed state-dependent differences, with interictal phase participants exhibiting higher amplitudes than those in the migraine attack phase.
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Positive associations were found between contingent negative variation amplitudes and facial pulsation metrics, indicating angiosome-dependent relationships.
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The findings suggest increased facial pulsation asymmetry and phase asynchrony in migraine, highlighting the need for further validation in larger cohorts.

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