Dynamic hyperinflammatory response assessment using HIC scores in COVID-19: application to a large series of patients receiving anakinra - Takeaways - MDSpire

Dynamic hyperinflammatory response assessment using HIC scores in COVID-19: application to a large series of patients receiving anakinra

  • By

  • Shirkhan Amikishiyev

  • Rabia Deniz

  • Mehmet Guven Gunver

  • Sarvan Aghamuradov

  • Nevzat Koca

  • Burak Ince

  • Murat Bektas

  • Aysenur Yilmaz

  • Yagmur Canturk

  • Gorkem Durak

  • Murat Kose

  • Mustafa Erelel

  • Arif Atahan Çağatay

  • Serap Simsek Yavuz

  • Sevgi Kalayoglu Besisik

  • Figen Esen

  • Ahmet Gül

  • May 22, 2026

  • 0 min

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  • 1

    The study analyzed 218 hospitalized COVID-19 patients with hyperinflammation treated with anakinra, focusing on mortality and inflammatory markers.

  • 2

    Overall in-hospital mortality was 12.8%, with survivors showing earlier CRP reduction compared to non-survivors.

  • 3

    Divergence in HIC scores and inflammatory parameters was observed within 3–4 days of anakinra treatment.

  • 4

    ROC analysis indicated that HIC scores at treatment initiation and final assessment effectively discriminated between survivors and non-survivors.

  • 5

    The findings support the HIC score as a dynamic monitoring tool for treatment response during IL-1 blockade in COVID-19.

Original Source(s)

Dynamic hyperinflammatory response assessment using HIC scores in COVID-19: application to a large series of patients receiving anakinra

  • by Shirkhan Amikishiyev, Rabia Deniz, Mehmet Guven Gunver, Sarvan Aghamuradov, Nevzat Koca, Burak Ince, Murat Bektas, Aysenur Yilmaz, Yagmur Canturk, Gorkem Durak, Murat Kose, Mustafa Erelel, Arif Atahan Çağatay, Serap Simsek Yavuz, Sevgi Kalayoglu Besisik, Figen Esen, Ahmet Gül

  • May 22, 2026

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