Design of the LEONORA Randomized Clinical Trial: Impact of Synbiotic Prophylaxis on Lower Gastrointestinal Symptoms Following Colorectal Cancer Surgery - Takeaways - MDSpire

Design of the LEONORA Randomized Clinical Trial: Impact of Synbiotic Prophylaxis on Lower Gastrointestinal Symptoms Following Colorectal Cancer Surgery

  • By

  • Ben Schöttker

  • Annette Kopp-Schneider

  • Lena Biehl

  • March 25, 2026

  • 0 min

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  • 1

    The LEONORA trial aims to assess the impact of synbiotic prophylaxis on gastrointestinal quality of life in colorectal cancer patients post-surgery.

  • 2

    This study will involve 206 patients, making it the largest placebo-controlled RCT on synbiotics for postoperative complications in CRC.

  • 3

    The trial will utilize a diverse probiotic formulation and a potent prebiotic, with treatment lasting 90 days compared to previous studies.

  • 4

    Stool samples will be collected to analyze changes in microbiota composition and assess the emergence of multidrug-resistant organisms.

  • 5

    The study will also evaluate rates of infection, inflammatory biomarkers, and recurrence-free survival among participants.

Original Source(s)

Design of the LEONORA Randomized Clinical Trial: Impact of Synbiotic Prophylaxis on Lower Gastrointestinal Symptoms Following Colorectal Cancer Surgery

  • by Ben Schöttker, Annette Kopp-Schneider, Lena Biehl

  • March 25, 2026

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