Interconnection of Differentiated Thyroid Cancer and Cardiovascular Disease: Insulin Resistance as a Potential Molecular Link—A Proposed Mechanism

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Differentiated thyroid cancer (DTC) is linked to increased cardiovascular disease (CVD) risk, particularly in long-term survivors.
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Insulin resistance (IR) may serve as a molecular link between DTC and cardiovascular vulnerability, although direct evidence is limited.
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The proposed DTC–IR–CVD axis suggests tumor-related metabolic changes contribute to endothelial dysfunction and myocardial remodeling.
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DTC's metabolic reprogramming involves oncogenic alterations that promote glycolysis and may lead to systemic nutrient sequestering.
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The article presents a hypothesis-generating framework for future studies on the relationship between DTC, IR, and cardiovascular risk.

Frontiers In Endocrinology

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