Bimodal ultrasound assessment of cerebral hemodynamics in preterm infants stratified by maternal immunotherapy: implications for early prediction of intraventricular hemorrhage - Takeaways - MDSpire

Bimodal ultrasound assessment of cerebral hemodynamics in preterm infants stratified by maternal immunotherapy: implications for early prediction of intraventricular hemorrhage

  • By

  • Na Wu

  • Rui Cao

  • July 14, 2026

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  • 1

    The study evaluated bedside bimodal ultrasound for assessing cerebral circulation in preterm infants with maternal recurrent spontaneous abortion.

  • 2

    A total of 120 preterm infants were enrolled, with assessments performed on postnatal days 1, 3, 5, and 7.

  • 3

    Significant time effects and group interactions were found for pulsatility index and optic nerve sheath diameter, indicating dynamic changes.

  • 4

    The bimodal ultrasound model showed an AUC of 0.759, while the expanded model had an AUC of 0.817, indicating good predictive performance.

  • 5

    Maternal immunotherapy status influenced cerebral hemodynamic trajectories, but findings do not confirm a direct protective effect on IVH risk.

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