CD4 T cell phenotype after AS01-adjuvanted immunization is shaped by prior antigen or pathogen exposure - Takeaways - MDSpire

CD4 T cell phenotype after AS01-adjuvanted immunization is shaped by prior antigen or pathogen exposure

  • By

  • Robbert G. van der Most

  • Geert Leroux-Roels

  • June 22, 2026

  • 0 min

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  • 1

    CD4 T-cell responses are crucial for the protection provided by many vaccines and can be enhanced by adjuvants like AS01.

  • 2

    AS01 is included in several licensed vaccines, such as those for zoster, RSV, malaria, and a TB vaccine candidate.

  • 3

    The capacity of vaccine-induced CD4 T cells to produce interferon-γ is influenced by prior exposure to pathogens.

  • 4

    Pre-existing immune memory shapes the quantity and quality of CD4 T-cell responses following vaccination.

  • 5

    Clinical studies have shown that AS01-adjuvanted vaccines can significantly increase the polyfunctionality of CD4 T cells.

Original Source(s)

CD4 T cell phenotype after AS01-adjuvanted immunization is shaped by prior antigen or pathogen exposure

  • by Robbert G. van der Most, Geert Leroux-Roels

  • June 22, 2026

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