The prognostic significance of immunohistochemical expressions of proliferating cell nuclear antigen, P16 and Ki-67 in breast cancer - Takeaways - MDSpire

The prognostic significance of immunohistochemical expressions of proliferating cell nuclear antigen, P16 and Ki-67 in breast cancer

  • By

  • Ali Duran

  • Hüseyin Pulat

  • Özlem Gübür

  • Eren Altun

  • Burak Yavuz

  • Ugur Topal

  • Alev Çetin Duran

  • July 16, 2026

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  • 1

    This study examines the prognostic value of proliferation markers PCNA, p16, and Ki-67 in breast cancer patients.

  • 2

    PCNA scores showed no association with demographic or clinical features, but a significant correlation with p16 was observed.

  • 3

    Higher Ki-67 index correlated with decreased ER and PR expression and was associated with shorter overall survival.

  • 4

    Neither PCNA nor p16 demonstrated independent prognostic significance regarding overall survival in the cohort.

  • 5

    Ki-67 remains the most informative proliferation marker for prognostic stratification in breast cancer.

Original Source(s)

The prognostic significance of immunohistochemical expressions of proliferating cell nuclear antigen, P16 and Ki-67 in breast cancer

  • by Ali Duran, Hüseyin Pulat, Özlem Gübür, Eren Altun, Burak Yavuz, Ugur Topal, Alev Çetin Duran

  • July 16, 2026

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