Strategies for Hybrid Immunity: Combining Heterologous Vaccination with Natural SARS-CoV-2 Infection

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Hybrid immunity combines natural infection and vaccination, providing stronger and more durable immune protection against SARS-CoV-2.
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Heterologous vaccination, using different vaccine platforms, enhances the breadth and potency of immune responses compared to homologous regimens.
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The continuous evolution of SARS-CoV-2 variants challenges existing immune barriers, necessitating improved vaccination strategies.
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Hybrid immunity leverages the synergistic effects of diverse antigen exposures, resulting in superior immune protection.
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Adopting heterologous vaccination as a public health strategy can optimize hybrid immunity and counteract viral evolution.

Frontiers In Medicine

by Yuan Huang, Xiaolu Zhang, Ruixia Miao, Jing Wang, Xuan Xi, Heng Pan, Yan Lu, Dehong Li
April 21, 2026

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