Fraxinellone mitigates acute lung injury by targeting HIF-1α to suppress pyroptosis and inflammation - Takeaways - MDSpire

Fraxinellone mitigates acute lung injury by targeting HIF-1α to suppress pyroptosis and inflammation

  • By

  • Bing Zhang

  • Xiaoning Lu

  • Yuefei Zhang

  • Xinyu Shen

  • Zhongbing Tan

  • Junling Leng

  • Yifei Chen

  • Hui Shen

  • Yong Li

  • July 16, 2026

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  • 1

    Fraxinellone (FRA) inhibits HIF-1α synthesis, reducing inflammation and pyroptosis in acute pulmonary contusion (APC) models.

  • 2

    In vivo and in vitro studies demonstrated that FRA significantly decreases pro-inflammatory cytokines and pulmonary edema.

  • 3

    Molecular docking revealed that FRA binds to HIF-1α at Arg258, confirming its role in mitigating APC severity.

  • 4

    HIF-1α knockdown and mutation replicated the anti-pyroptotic effects of FRA, indicating pathway specificity.

  • 5

    FRA presents a novel therapeutic approach for APC by targeting the HIF-1α-NLRP3 axis to suppress inflammation.

Original Source(s)

Fraxinellone mitigates acute lung injury by targeting HIF-1α to suppress pyroptosis and inflammation

  • by Bing Zhang, Xiaoning Lu, Yuefei Zhang, Xinyu Shen, Zhongbing Tan, Junling Leng, Yifei Chen, Hui Shen, Yong Li

  • July 16, 2026

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