Reduced heart rate variability predicts incident diabetic polyneuropathy - Takeaways - MDSpire

Reduced heart rate variability predicts incident diabetic polyneuropathy

  • By

  • Dimitrios Tsilingiris

  • Daniel Schmalzridt

  • Omar Eldesouky

  • Florian Kalb

  • Viktoria Flegka

  • Ekaterina von Rauchhaupt

  • Theresa Hoefer

  • Stefan Kopf

  • Thomas Fleming

  • Stephan Herzig

  • Anna Hohneck

  • Julia Szendroedi

  • Zoltan Kender

  • July 16, 2026

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  • 1

    The study assessed whether cardiovascular autonomic neuropathy (CAN) and reduced heart rate variability (HRV) predict distal symmetrical polyneuropathy (DSPN) in diabetes.

  • 2

    Among 288 individuals with diabetes, CAN prevalence was 16.3%, and low HRV indices were found in 18.6–40.2% of participants.

  • 3

    DSPN prevalence varied based on definitions: 27.7% for clinical criteria, 17.6% for sensory-loss phenotype, and 20.8% for the Toronto consensus definition.

  • 4

    Baseline CAN independently predicted incident DSPN, with adjusted hazard ratios ranging from 3.30 to 7.33 across different definitions.

  • 5

    Reduced HRV metrics, including lower rMSSD and power indices, were identified as predictors of incident DSPN according to specific definitions.

Original Source(s)

Reduced heart rate variability predicts incident diabetic polyneuropathy

  • by Dimitrios Tsilingiris, Daniel Schmalzridt, Omar Eldesouky, Florian Kalb, Viktoria Flegka, Ekaterina von Rauchhaupt, Theresa Hoefer, Stefan Kopf, Thomas Fleming, Stephan Herzig, Anna Hohneck, Julia Szendroedi, Zoltan Kender

  • July 16, 2026

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