Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a single-center cohort from Japan - Takeaways - MDSpire

Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a single-center cohort from Japan

  • By

  • Hideyo Kasai

  • Taro Yasumoto

  • Shota Kosuge

  • Ayako Osanai

  • Keita Mizuma

  • Akinori Futamura

  • Takeshi Kuroda

  • Kenjiro Ono

  • Hidetomo Murakami

  • May 13, 2026

  • 0 min

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  • 1

    A total of 50 patients initiated anti-CGRP monoclonal antibody treatment, with 28 (56%) maintaining therapy for three years.

  • 2

    Monthly migraine days decreased significantly from 12.0 to 5.6 over three years, alongside improvements in disability and quality of life measures.

  • 3

    Responder rates for treatment efficacy remained stable, with 55.6% achieving a ≥50% reduction in monthly migraine days at 36 months.

  • 4

    Treatment cessation often occurred after achieving therapeutic goals, with only 24% discontinuing for this reason and no discontinuations due to adverse events.

  • 5

    The study highlights the long-term efficacy and tolerability of anti-CGRP monoclonal antibodies, supporting personalized treatment decisions in migraine management.

Original Source(s)

Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a single-center cohort from Japan

  • by Hideyo Kasai, Taro Yasumoto, Shota Kosuge, Ayako Osanai, Keita Mizuma, Akinori Futamura, Takeshi Kuroda, Kenjiro Ono, Hidetomo Murakami

  • May 13, 2026

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