Anti-CGRP antibodies may raise miscarriage risk - Takeaways - MDSpire
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Anti-CGRP antibodies may raise miscarriage risk

Findings from 7,579 pregnancies suggest a potential safety concern with migraine prevention during early pregnancy.

  • By

  • Andrea Surnit

  • October 28, 2026

  • 4 min

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  • 1

    In a retrospective cohort of 7,579 pregnancies among patients with pregestational migraine, 1,862 spontaneous abortions occurred by 20 weeks.

  • 2

    Anti-CGRP monoclonal antibody exposure was associated with a 42% higher adjusted hazard of spontaneous abortion.

  • 3

    The estimated risk by 20 weeks was 28.7% under a hypothetical scenario of universal anti-CGRP exposure and 24.5% without exposure.

  • 4

    Propranolol exposure was not associated with an increased hazard of spontaneous abortion, including after bias adjustment for migraine severity.

  • 5

    The observational study could not establish causality, and claims data, residual confounding, and limited exposed pregnancies constrained interpretation.

Original Source(s)

Anti-CGRP antibodies may raise miscarriage risk

  • by Andrea Surnit

  • October 28, 2026

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