Risk factors associated with growth pain disorder in children: a systematic review and meta-analysis

1

The systematic review included 37 studies with 16,086 participants, identifying 17 potential risk factors for growth pain disorder in children.
2

Children with growth pain disorder exhibited lower serum 25-hydroxyvitamin D concentrations and lower bone density compared to healthy peers.
3

Hypermobility and physical activity were correlated with growth pain disorder, with overactivity and joint hypermobility more prevalent in affected children.
4

Genetic factors, family history, and psychosocial status may contribute to the onset of growth pain disorder in pediatric populations.
5

The study emphasizes the need for high-quality prospective research to better understand the risk factors influencing growth pain disorder.

Frontiers In Pediatrics

1