Plasma Ceramides Levels in Severe COVID-19 Disease: Correlations with Survival - Takeaways - MDSpire

Plasma Ceramides Levels in Severe COVID-19 Disease: Correlations with Survival

  • By

  • Tri Pham

  • Andrea M Heredia Castillo

  • Andrew Atkinson

  • Linda R Peterson

  • M Cristina Vazquez Guillamet

  • February 5, 2026

  • 0 min

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  • 1

    Ceramides are bioactive lipids involved in inflammatory signaling and may serve as prognostic markers in severe COVID-19 cases.

  • 2

    Higher plasma levels of ceramides C16, C22, and C24 were observed in nonsurvivors during the first week of illness compared to survivors.

  • 3

    The trajectories of ceramides C16, C22, and C24 differed from traditional inflammatory markers, suggesting unique behavior in COVID-19.

  • 4

    A higher C24/C16 ratio emerged as a robust predictor of more favorable outcomes in severe COVID-19 patients.

  • 5

    Further research is needed to explore ceramide dynamics in the acute-to-subacute phases of COVID-19 disease.

Original Source(s)

Plasma Ceramides Levels in Severe COVID-19 Disease: Correlations with Survival

  • by Tri Pham, Andrea M Heredia Castillo, Andrew Atkinson, Linda R Peterson, M Cristina Vazquez Guillamet

  • February 5, 2026

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