Distinct Metabolic and Inflammation Signatures in Urban vs Rural Ugandan Youth With HIV on Dolutegravir

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The study compared metabolic and inflammatory profiles of Ugandan youth with perinatally acquired HIV from urban and rural settings.
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Rural youth with HIV experienced higher levels of systemic inflammation despite lower viral loads compared to their urban counterparts.
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Urban participants had higher body mass index and cholesterol levels, while rural participants showed elevated inflammatory markers like sCD14.
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Extreme poverty significantly affected rural youth, highlighting the need for targeted healthcare interventions in these populations.
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The findings emphasize the importance of including rural populations in HIV research to address comorbidities in aging youth with HIV.

Open Forum Infectious Diseases

by Sahera Dirajlal-Fargo, Shan Sun, Kate Ailstock, Morgan Cummings, Nate Lucas, Rashida Nazzinda, Christine Karungi, Daisy Faith Oryem, Robert Kidega, Victor Musiime, Cissy Kityo, Grace A McComsey, Nicholas Funderburg
July 18, 2025

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