The Case for Simulating Pregnancy - Takeaways - MDSpire

The Case for Simulating Pregnancy

Why drug trials exclude pregnant women – and how simulation could change that

  • By

  • Jessica Allerton

  • June 2, 2026

  • 11 min

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  • 1

    Karen Yeo emphasizes the importance of pharmacokinetic modeling in addressing drug use gaps during pregnancy.

  • 2

    Pregnant women are often excluded from clinical trials, leading to limited data for informed treatment decisions.

  • 3

    Physiological changes during pregnancy significantly affect drug metabolism, necessitating tailored dosing guidelines.

  • 4

    Physiologically based pharmacokinetic modeling can identify data gaps and foster collaboration for better drug research.

  • 5

    Improving communication and evidence availability is crucial for encouraging pregnant women to participate in clinical research.

Original Source(s)

The Case for Simulating Pregnancy

  • by Jessica Allerton

  • June 2, 2026

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