Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation - Takeaways - MDSpire

Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation

  • By

  • Kentaro Fukushima

  • Hayami Kudo

  • Kentaro Oka

  • Atsushi Hayashi

  • Makoto Onizuka

  • Shinsuke Kusakabe

  • Akihisa Hino

  • Motomichi Takahashi

  • Kiyoshi Takeda

  • Masaki Mori

  • Kiyoshi Ando

  • Naoki Hosen

  • March 2, 2024

  • 0 min

Share

  • 1

    Clostridium butyricum MIYAIRI 588 (CBM588) is classified as a live biotherapeutic product and is used to treat microbial dysbiosis-related symptoms.

  • 2

    CBM588 administration improves intestinal microbiota balance by increasing beneficial bacteria such as Bifidobacterium and Lactobacillus.

  • 3

    The study evaluated the effects of prophylactic CBM588 on intestinal microbiota in patients undergoing haematopoietic stem cell transplantation.

  • 4

    Forty Japanese patients were included in the study, with faecal samples collected before and after HSCT for microbiota analysis.

  • 5

    The ongoing randomized pilot study aims to assess the safety and feasibility of CBM588 during the peri-transplant period.

Original Source(s)

Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation

  • by Kentaro Fukushima, Hayami Kudo, Kentaro Oka, Atsushi Hayashi, Makoto Onizuka, Shinsuke Kusakabe, Akihisa Hino, Motomichi Takahashi, Kiyoshi Takeda, Masaki Mori, Kiyoshi Ando, Naoki Hosen

  • March 2, 2024

Related Content

Antibiotic use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database

Compositional maturation of the microbiome and adaptive immunity in the postnatal period

Renal Conditions Associated with Inflammatory Bowel Disease: Exploring Clinical Links, Shared Mechanisms, and Management Approaches