Circulating Soluble Factors and T-Cell Subsets as Immunological Predictors of Therapy Response in Human Cutaneous Leishmaniasis - Takeaways - MDSpire

Circulating Soluble Factors and T-Cell Subsets as Immunological Predictors of Therapy Response in Human Cutaneous Leishmaniasis

  • By

  • Amanda B Figueiredo

  • Katia L P Morais

  • Israel T Silva

  • Lorhenn B L Maia

  • Jaqueline R Buttura

  • Bruna D F Barros

  • Natalia S Alves

  • Flavio Pignataro-Oshiro

  • Samara M M Shimon

  • Andrea Teixeira-Carvalho

  • Lucas Almeida

  • Edgar Carvalho

  • Paulo Machado

  • Jenefer M Blackwell

  • Lea Castellucci

  • Walderez O Dutra

  • Kenneth J Gollob

  • February 4, 2025

  • 0 min

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  • 1

    Human cutaneous leishmaniasis, caused by Leishmania braziliensis, presents significant treatment challenges due to variable therapeutic responses.

  • 2

    A study identified circulating soluble factors as promising noninvasive predictive markers for treatment outcomes in cutaneous leishmaniasis.

  • 3

    Elevated frequencies of CD8+ mucosal-associated invariant T (MAIT) cells are associated with increased lesion pathology and treatment refractoriness.

  • 4

    The balance of cytokines and T-cell responses plays a crucial role in the immunopathogenesis of cutaneous leishmaniasis and treatment efficacy.

  • 5

    Findings suggest potential for tailored therapeutic strategies and novel immunomodulatory approaches to improve treatment outcomes in refractory cases.

Original Source(s)

Circulating Soluble Factors and T-Cell Subsets as Immunological Predictors of Therapy Response in Human Cutaneous Leishmaniasis

  • by Amanda B Figueiredo, Katia L P Morais, Israel T Silva, Lorhenn B L Maia, Jaqueline R Buttura, Bruna D F Barros, Natalia S Alves, Flavio Pignataro-Oshiro, Samara M M Shimon, Andrea Teixeira-Carvalho, Lucas Almeida, Edgar Carvalho, Paulo Machado, Jenefer M Blackwell, Lea Castellucci, Walderez O Dutra, Kenneth J Gollob

  • February 4, 2025

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