How Does That Large Language Model Make You Feel? By Simon Spichak June 30, 2026 0 min Journal Of Medical Internet Research (Jmir) Share Summary Takeaways Listen Insight Report Clinical Scorecard Quiz Poll Top Institutions 1 Many people are using large language models (LLMs) for mental health support despite a lack of data on safety and effectiveness. 2 Experts call for more research to understand the safety and effectiveness of LLMs compared to traditional mental health treatments. 3 General-purpose LLMs can produce direct harm and may reinforce detrimental behaviors in mental health contexts. 4 Clinically validated chatbots are being developed, but their effectiveness compared to general-purpose LLMs remains untested. 5 Clinicians should maintain open dialogue with clients using LLMs to understand their use and improve therapeutic outcomes.