Case Report: Penile malignant melanoma: insights from a three-case series and literature review on diagnosis and management - Takeaways - MDSpire

Case Report: Penile malignant melanoma: insights from a three-case series and literature review on diagnosis and management

  • By

  • Xiaoxiao Xu

  • Xiaolong Hou

  • Hongze Li

  • Yiming Chen

  • Bohao Jiang

  • Hao Zhang

  • July 17, 2026

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  • 1

    Penile melanoma is a rare and aggressive form of mucosal melanoma, accounting for less than 2% of penile tumors.

  • 2

    The study presents three cases of primary penile melanoma, all treated surgically, with varying outcomes.

  • 3

    Surgical treatment, including local or partial penectomy, is the primary management option for penile melanoma.

  • 4

    Adjuvant therapies such as chemotherapy and radiotherapy are used to prevent recurrence, with novel treatments under evaluation.

  • 5

    Further clinical research is necessary to establish standardized protocols for the diagnosis and management of penile melanoma.

Original Source(s)

Case Report: Penile malignant melanoma: insights from a three-case series and literature review on diagnosis and management

  • by Xiaoxiao Xu, Xiaolong Hou, Hongze Li, Yiming Chen, Bohao Jiang, Hao Zhang

  • July 17, 2026

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