Persistence of M-proteins detected by mass spectrometry - Takeaways - MDSpire
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Detection of M-proteins via mass spectrometry: A persistent finding

  • By

  • David L. Murray

  • Jonathan Coker

  • Taxiarchis Kourelis

  • Angela Dispenzieri

  • Mindy Kohlhagen

  • Surendra Dasari

  • Maria Willrich

  • August 20, 2026

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  • 1

    Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell proliferative disorder in individuals over 50.

  • 2

    Mass spectrometry (MS) techniques like Mass-Fix have replaced traditional methods for detecting M-proteins, offering improved sensitivity and specificity.

  • 3

    In a study of 6035 MGUS patients, 97% showed persistence of M-proteins detected by Mass-Fix over a minimum of 6 months.

  • 4

    Low-level M-proteins identified by Mass-Fix exhibited higher persistence rates compared to those detected by immunofixation electrophoresis.

  • 5

    The study suggests that low-level M-proteins identified by Mass-Fix are likely to be genuine MGUS, although they may represent low-risk cases.

Original Source(s)

Persistence of M-proteins detected by mass spectrometry

  • by David L. Murray, Jonathan Coker, Taxiarchis Kourelis, Angela Dispenzieri, Mindy Kohlhagen, Surendra Dasari, Maria Willrich

  • August 20, 2026

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