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New Perspectives on Immune Cell Mechanisms in Inflammation-Induced Atherosclerosis

  • By

  • Abdullahi Osman Mohamud

  • Zhiyin Dai

  • July 2, 2026

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  • 1

    Atherosclerosis is a chronic inflammatory disease characterized by lipid deposition and calcification in major arteries.

  • 2

    Endothelial activation increases vascular permeability and promotes leukocyte adhesion, leading to inflammatory cell migration.

  • 3

    Single-cell RNA sequencing reveals substantial heterogeneity among immune cells in atherosclerotic plaques.

  • 4

    Major cardiovascular risk factors initiate endothelial dysfunction, promoting chronic vascular inflammation and plaque progression.

  • 5

    Systemic factors like gut microbiota and epigenetic changes contribute to trained immunity and meta-inflammation in atherosclerosis.

Original Source(s)

Emerging insights into inflammation-driven atherosclerosis: immune cell mechanisms

  • by Abdullahi Osman Mohamud, Zhiyin Dai

  • July 2, 2026

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