Young Blood Slows Alzheimer’s in Mice
Proteomics connects exposure to blood from older donors and synaptic dysfunction in the brain
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Young blood infusions in mice reduce Alzheimer’s-like pathology and improve cognitive performance compared to older blood.
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Mice receiving aged blood exhibited increased amyloid-β deposition and impaired memory, highlighting systemic influences on neurodegeneration.
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Proteomic analysis identified 256 proteins with differential expression linked to synaptic signaling and neuronal regulation.
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The α2δ2 subunit of voltage-gated calcium channels was upregulated in mice infused with aged blood, suggesting synaptic dysfunction.
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The study opens avenues for exploring therapeutic targets related to the blood-brain axis in Alzheimer's disease.
