Association of oxidative stress, metacognition, and psychopathology in patients with schizophrenia: a case-control study - Takeaways - MDSpire

Association of oxidative stress, metacognition, and psychopathology in patients with schizophrenia: a case-control study

  • By

  • Xiaojuan Hu

  • Jun Cheng

  • Shoucui Xia

  • Lili Ma

  • Yang Zhang

  • Li Zhang

  • Xiaojing Meng

  • Xulai Zhang

  • Dongmei Wang

  • Aiguo Zhang

  • July 1, 2026

  • 0 min

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  • 1

    Schizophrenia patients exhibit significant metacognitive deficits compared to healthy controls, as measured by the Metacognitive Assessment Scale.

  • 2

    Oxidative stress markers in schizophrenia patients show lower levels of SOD, CAT, and GPX, and higher levels of MDA compared to healthy controls.

  • 3

    Partial correlation analysis indicates that oxidative stress markers correlate with both metacognitive and psychopathological scores in schizophrenia patients.

  • 4

    Linear regression analysis reveals significant associations between oxidative stress markers and the total scores on the PANSS and MAS-A.

  • 5

    The study suggests that oxidative stress may be a key factor linking metacognitive impairments and psychopathological symptoms in schizophrenia.

Original Source(s)

Association of oxidative stress, metacognition, and psychopathology in patients with schizophrenia: a case-control study

  • by Xiaojuan Hu, Jun Cheng, Shoucui Xia, Lili Ma, Yang Zhang, Li Zhang, Xiaojing Meng, Xulai Zhang, Dongmei Wang, Aiguo Zhang

  • July 1, 2026

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