Realizing the value of the divergence event in clinical human-AI interaction - Takeaways - MDSpire
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Recognizing the Significance of Divergence in Clinical Human–AI Interactions

  • By

  • Florence X. Doo

  • Gabriel A. Brat

  • Sarah C. Rossetti

  • Robert Klitzman

  • Charles E. Binkley

  • October 13, 2026

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  • 1

    Human-AI divergence visibility documents how clinicians and AI interact when their outputs differ, rather than treating the event as a simple choice to accept or override.

  • 2

    Divergence can arise from different information available to clinicians and AI, genuine differences in interpreting shared evidence, or an error by either party.

  • 3

    Clinicians contribute bedside examination, communication, and procedural information, whereas AI systems process structured records and patterns from prior cases or databases.

  • 4

    Technical explanations of an AI output do not reveal why the clinician’s judgment and the AI’s conclusion diverged, and post hoc explanations may foster false confidence in erroneous outputs.

  • 5

    The article argues that dedicated visibility metrics are needed to examine the human-AI interaction and identify what each contributed when their outputs diverged.

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