Development of an improved preclinical humanized mouse platform representing the diverse clinical phenotypes of Sjögren’s syndrome - Takeaways - MDSpire

Development of an improved preclinical humanized mouse platform representing the diverse clinical phenotypes of Sjögren’s syndrome

  • By

  • Jin-Sil Park

  • JeongWon Choi

  • Ha Yeon Jeong

  • Hye Yeon Kang

  • Sang Hee Cho

  • Su Beom Lee

  • Mi-La Cho

  • Sung-Hwan Park

  • May 22, 2026

  • 0 min

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  • 1

    A humanized murine model of Sjögren’s syndrome (SS) was developed using PBMCs from SS patients to study disease mechanisms and therapeutic strategies.

  • 2

    The model exhibited increased infiltration of IL-17-producing T cells and significant immune cell infiltration in salivary glands, mimicking human SS pathology.

  • 3

    Histopathological analysis revealed reduced Aquaporin-5 expression in salivary glands of mice injected with SS-derived PBMCs.

  • 4

    Metformin treatment significantly reduced salivary gland inflammation and pathogenic T cell infiltration in the humanized SS model.

  • 5

    This enhanced model serves as a valuable preclinical platform for investigating the pathogenesis and treatment of Sjögren’s syndrome.

Original Source(s)

Development of an improved preclinical humanized mouse platform representing the diverse clinical phenotypes of Sjögren’s syndrome

  • by Jin-Sil Park, JeongWon Choi, Ha Yeon Jeong, Hye Yeon Kang, Sang Hee Cho, Su Beom Lee, Mi-La Cho, Sung-Hwan Park

  • May 22, 2026

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