Commentary: Safety and efficacy of a novel fecal microbiota transplantation method using hydrogen nanobubble water without antibiotics or bowel cleansing in children with autism spectrum disorder

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A novel fecal microbiota transplantation technique using hydrogen nanobubble water shows a 29% reduction in SRS-2 scores in pediatric ASD patients.
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The study's single-arm design limits the ability to attribute improvements specifically to the new treatment rather than natural developmental changes.
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The absence of control conditions raises concerns about expectancy effects and regression to the mean impacting the observed treatment outcomes.
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Secondary outcomes lack correction for multiple comparisons, necessitating cautious interpretation of findings related to anxiety and depressive symptoms.
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Future research should include a randomized, placebo-controlled trial to validate the efficacy and safety of this fecal microbiota transplantation method.

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