Anti-Diabetic Retinopathy Molecular Mechanism of Dihuang Yinzi: Insights from Network Pharmacology, Metabolomics, and Microbiome Analysis - Takeaways - MDSpire

Anti-Diabetic Retinopathy Molecular Mechanism of Dihuang Yinzi: Insights from Network Pharmacology, Metabolomics, and Microbiome Analysis

  • By

  • Chai, Jinmiao

  • Gui, Wanwei

  • Zhang, Junlong

  • He, Wenbin

  • Li, Qinqing

  • April 28, 2026

  • 0 min

Share

  • 1

    Diabetic retinopathy (DR) is a complex microvascular complication of diabetes involving genetic, metabolic, and microbial factors.

  • 2

    Dihuang Yinzi (DHYZ) shows potential as a therapeutic remedy for DR, but its mechanisms require further investigation.

  • 3

    The study identified 110 candidate genes and five primary target genes related to DHYZ's efficacy against DR.

  • 4

    Molecular docking revealed strong binding interactions between ESR1 and active compounds, particularly naringenin.

  • 5

    The research highlighted 30 key metabolites and 18 key microbes that may mediate DHYZ's therapeutic effects in DR.

Original Source(s)

Anti-Diabetic Retinopathy Molecular Mechanism of Dihuang Yinzi: Insights from Network Pharmacology, Metabolomics, and Microbiome Analysis

  • by Chai, Jinmiao , Gui, Wanwei , Zhang, Junlong , He, Wenbin , Li, Qinqing

  • April 28, 2026

Related Content

Advancing Retinal Imaging for Cardiovascular Risk Assessment

Assessment of Hypertensive Retinopathy Severity and Associated Factors in Adult Patients at Ophthalmic Clinics in Northern Ethiopia: A Multicenter Cross-Sectional Analysis

Retina Biomarkers for Treatment Selection in DME