Neutrophil immunometabolism in ACLF and sepsis: mechanisms, dysfunction, and therapeutic opportunities - Takeaways - MDSpire

Neutrophil immunometabolism in ACLF and sepsis: mechanisms, dysfunction, and therapeutic opportunities

  • By

  • Sonali Mukherjee

  • Takhellambam Malemnganba

  • Pragyan Acharya

  • May 22, 2026

  • 0 min

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  • 1

    Neutrophils in ACLF and sepsis exhibit metabolic reprogramming that drives hyperinflammation and immune dysfunction.

  • 2

    ACLF develops on a background of chronic liver disease, leading to a constrained immune response compared to sepsis.

  • 3

    Both conditions share features like glycolysis-driven reprogramming and excessive ROS generation, exacerbating tissue injury.

  • 4

    Neutrophil dysfunction in ACLF and sepsis is characterized by simultaneous hyperactivation and functional paralysis.

  • 5

    A unified framework linking neutrophil immunometabolism to disease pathogenesis remains lacking, particularly in ACLF.

Original Source(s)

Neutrophil immunometabolism in ACLF and sepsis: mechanisms, dysfunction, and therapeutic opportunities

  • by Sonali Mukherjee, Takhellambam Malemnganba, Pragyan Acharya

  • May 22, 2026

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