Investigation of Lactylation-Associated Genes and Their Relationship with the Development of Diabetic Foot Ulcers and Immune Cell Infiltration

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Diabetic foot ulcers (DFUs) are serious complications of diabetes, leading to chronic wounds and high amputation risks.
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Lactylation, a post-translational modification, plays a critical role in immune response and gene expression related to DFUs.
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The study identified 1,234 differentially expressed genes, with 38 overlapping lactylation-related genes significantly downregulated in DFUs.
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Core lactylation-associated genes CHD4, EEF1A1, and EEF1G showed significant downregulation and strong classification performance in DFU.
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Findings suggest lactylation may serve as a regulatory mechanism in DFU pathogenesis, highlighting potential biomarkers and therapeutic targets.

Frontiers In Immunology

by Xiaolong Hu, Junpeng Zhou, Meng Guo, Wei Peng, Chen Yang, Fang Wang, Wei Zhang, Jiaqi Liu
April 29, 2026

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