Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes - Takeaways - MDSpire

Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes

  • By

  • Heba M Ismail

  • Dimuthu Perera

  • Rabindra Mandal

  • Linda A DiMeglio

  • Carmella Evans-Molina

  • Tamara Hannon

  • Joseph Petrosino

  • Sara Javornik Cregeen

  • Nathan W Schmidt

  • July 31, 2024

  • 0 min

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  • 1

    Obesity prevalence in adolescents with type 1 diabetes (T1D) can reach 46.1%, increasing the risk of diabetes complications.

  • 2

    The study identified significant differences in gut microbiome composition between lean and obese adolescents with T1D.

  • 3

    Obese adolescents exhibited a higher ratio of Prevotella to Bacteroides and increased relative abundance of Prevotella copri.

  • 4

    Functional profiling revealed upregulation of branched-chain amino acid biosynthesis in the obese group compared to the lean group.

  • 5

    Findings suggest that gut microbiome alterations may inform targeted therapies for managing obesity in adolescents with T1D.

Original Source(s)

Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes

  • by Heba M Ismail, Dimuthu Perera, Rabindra Mandal, Linda A DiMeglio, Carmella Evans-Molina, Tamara Hannon, Joseph Petrosino, Sara Javornik Cregeen, Nathan W Schmidt

  • July 31, 2024

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