Brain alteration of PCOS: neuroimaging and function - Takeaways - MDSpire

Brain alteration of PCOS: neuroimaging and function

  • By

  • Ningxiao Jiang

  • Jie Deng

  • Changjin Bao

  • Hongmei Yin

  • Xianghui Zhang

  • Yanxia Ding

  • Shinan Zhang

  • Yingjiang Xu

  • Xinghua Diao

  • Kexin Lu

  • Jun Liu

  • Lei Han

  • June 11, 2026

  • 0 min

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  • 1

    Polycystic ovary syndrome (PCOS) is linked to significant structural and functional brain abnormalities, impacting endocrine and metabolic profiles.

  • 2

    Neuroimaging studies reveal pituitary gland enlargement, reduced gray matter volume, and corpus callosum damage in PCOS patients.

  • 3

    Cerebral alterations in PCOS correlate with abnormal glucose metabolism, disordered eating behaviors, and cognitive-emotional changes.

  • 4

    Elevated μ-opioid receptor binding in emotion-related brain regions suggests limbic system dysfunction in PCOS.

  • 5

    Understanding neuroimaging changes in PCOS may inform biomarker-driven diagnostics and targeted therapeutic strategies.

Original Source(s)

Brain alteration of PCOS: neuroimaging and function

  • by Ningxiao Jiang, Jie Deng, Changjin Bao, Hongmei Yin, Xianghui Zhang, Yanxia Ding, Shinan Zhang, Yingjiang Xu, Xinghua Diao, Kexin Lu, Jun Liu, Lei Han

  • June 11, 2026

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